Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: Effects of intercalation, heterocyclic-fused area and side chains

Zhigang Li; Qing Yang; Xuhong Qian

doi:10.1016/j.bmcl.2005.02.053

Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: Effects of intercalation, heterocyclic-fused area and side chains

Zhigang Li
, Qing Yang
, Xuhong Qian^*

^*此作品的通讯作者

Dalian University of Technology
East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

29 引用（Scopus）

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A new family of 2-aminothiazonaphthalimides with different side chains as novel intercalative and visible light activatable photonucleases, was designed, synthesized and quantitatively evaluated. The order of their photocleaving abilities was parallel to that of their intercalative properties. The compound with linear heterocyclic-fused chromophore could intercalate into and photocleave DNA more efficiently than the one with angular heterocyclic-fused chromophore. B₂, the most efficient compound, caused obvious DNA damage at 1 μM. Mechanism experiment showed that superoxide anion was involved.

源语言	英语
页（从-至）	1769-1772
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	15
期	7
DOI	https://doi.org/10.1016/j.bmcl.2005.02.053
出版状态	已出版 - 1 4月 2005
已对外发布	是

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abstract = "A new family of 2-aminothiazonaphthalimides with different side chains as novel intercalative and visible light activatable photonucleases, was designed, synthesized and quantitatively evaluated. The order of their photocleaving abilities was parallel to that of their intercalative properties. The compound with linear heterocyclic-fused chromophore could intercalate into and photocleave DNA more efficiently than the one with angular heterocyclic-fused chromophore. B2, the most efficient compound, caused obvious DNA damage at 1 μM. Mechanism experiment showed that superoxide anion was involved.",

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T2 - Effects of intercalation, heterocyclic-fused area and side chains

AU - Li, Zhigang

AU - Yang, Qing

AU - Qian, Xuhong

PY - 2005/4/1

Y1 - 2005/4/1

N2 - A new family of 2-aminothiazonaphthalimides with different side chains as novel intercalative and visible light activatable photonucleases, was designed, synthesized and quantitatively evaluated. The order of their photocleaving abilities was parallel to that of their intercalative properties. The compound with linear heterocyclic-fused chromophore could intercalate into and photocleave DNA more efficiently than the one with angular heterocyclic-fused chromophore. B2, the most efficient compound, caused obvious DNA damage at 1 μM. Mechanism experiment showed that superoxide anion was involved.

AB - A new family of 2-aminothiazonaphthalimides with different side chains as novel intercalative and visible light activatable photonucleases, was designed, synthesized and quantitatively evaluated. The order of their photocleaving abilities was parallel to that of their intercalative properties. The compound with linear heterocyclic-fused chromophore could intercalate into and photocleave DNA more efficiently than the one with angular heterocyclic-fused chromophore. B2, the most efficient compound, caused obvious DNA damage at 1 μM. Mechanism experiment showed that superoxide anion was involved.

KW - Heterocycles

KW - Intercalation

KW - Photocleaver

KW - Plasmid DNA

UR - https://www.scopus.com/pages/publications/15044358598

U2 - 10.1016/j.bmcl.2005.02.053

DO - 10.1016/j.bmcl.2005.02.053

M3 - 文章

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SN - 0960-894X

VL - 15

SP - 1769

EP - 1772

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: Effects of intercalation, heterocyclic-fused area and side chains

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