Nickel/Titanocene-Catalyzed Electrophilic Acylation Coupling of Styrene Oxides

Jincan Li; Chang Cao; Haihong Wu; Kaiwu Dong

doi:10.1021/acs.orglett.3c02402

Nickel/Titanocene-Catalyzed Electrophilic Acylation Coupling of Styrene Oxides

Jincan Li
, Chang Cao
, Haihong Wu^*
, Kaiwu Dong^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

The cross-coupling of epoxides with acyl chlorides or anhydrides by a nickel/titanocene dual catalytic system is established. A variety of synthetically useful β-hydroxy ketones were obtained in good to high yields by using modified pyridine-oxazoline ligand. The reaction proceeds via the cooperation of titanocene-catalyzed ring-opening of epoxides and nickel-catalyzed acylation of the benzylic radical intermediate.

源语言	英语
页（从-至）	6959-6963
页数	5
期刊	Organic Letters
卷	25
期	38
DOI	https://doi.org/10.1021/acs.orglett.3c02402
出版状态	已出版 - 29 9月 2023

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abstract = "The cross-coupling of epoxides with acyl chlorides or anhydrides by a nickel/titanocene dual catalytic system is established. A variety of synthetically useful β-hydroxy ketones were obtained in good to high yields by using modified pyridine-oxazoline ligand. The reaction proceeds via the cooperation of titanocene-catalyzed ring-opening of epoxides and nickel-catalyzed acylation of the benzylic radical intermediate.",

author = "Jincan Li and Chang Cao and Haihong Wu and Kaiwu Dong",

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AU - Li, Jincan

AU - Cao, Chang

AU - Wu, Haihong

AU - Dong, Kaiwu

PY - 2023/9/29

Y1 - 2023/9/29

N2 - The cross-coupling of epoxides with acyl chlorides or anhydrides by a nickel/titanocene dual catalytic system is established. A variety of synthetically useful β-hydroxy ketones were obtained in good to high yields by using modified pyridine-oxazoline ligand. The reaction proceeds via the cooperation of titanocene-catalyzed ring-opening of epoxides and nickel-catalyzed acylation of the benzylic radical intermediate.

AB - The cross-coupling of epoxides with acyl chlorides or anhydrides by a nickel/titanocene dual catalytic system is established. A variety of synthetically useful β-hydroxy ketones were obtained in good to high yields by using modified pyridine-oxazoline ligand. The reaction proceeds via the cooperation of titanocene-catalyzed ring-opening of epoxides and nickel-catalyzed acylation of the benzylic radical intermediate.

UR - https://www.scopus.com/pages/publications/85172940873

U2 - 10.1021/acs.orglett.3c02402

DO - 10.1021/acs.orglett.3c02402

M3 - 文章

C2 - 37726896

AN - SCOPUS:85172940873

SN - 1523-7060

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SP - 6959

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JO - Organic Letters

JF - Organic Letters

IS - 38

ER -

Nickel/Titanocene-Catalyzed Electrophilic Acylation Coupling of Styrene Oxides

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