New method for the synthesis of 5-hydroxycamptothecin derivatives

Xungui He; Heyong Gao; Wei Lu; Junchao Cai

doi:10.1081/SCC-200039356

New method for the synthesis of 5-hydroxycamptothecin derivatives

Xungui He
, Heyong Gao
, Wei Lu^*
, Junchao Cai

^*此作品的通讯作者

CAS - Shanghai Institute of Materia Medica
Zhangjiang High-Tech Park

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

源语言	英语
页（从-至）	4285-4291
页数	7
期刊	Synthetic Communications
卷	34
期	23
DOI	https://doi.org/10.1081/SCC-200039356
出版状态	已出版 - 2004
已对外发布	是

访问文件

10.1081/SCC-200039356

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{358c6abddb2547d28e7d8b5d969aa1f8,

title = "New method for the synthesis of 5-hydroxycamptothecin derivatives",

abstract = "An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.",

keywords = "Antitumor, C ring, Camptothecin, Hydroxylation",

author = "Xungui He and Heyong Gao and Wei Lu and Junchao Cai",

year = "2004",

doi = "10.1081/SCC-200039356",

language = "英语",

volume = "34",

pages = "4285--4291",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "23",

}

TY - JOUR

T1 - New method for the synthesis of 5-hydroxycamptothecin derivatives

AU - He, Xungui

AU - Gao, Heyong

AU - Lu, Wei

AU - Cai, Junchao

PY - 2004

Y1 - 2004

N2 - An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

AB - An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

KW - Antitumor

KW - C ring

KW - Camptothecin

KW - Hydroxylation

UR - https://www.scopus.com/pages/publications/10644282957

U2 - 10.1081/SCC-200039356

DO - 10.1081/SCC-200039356

M3 - 文章

AN - SCOPUS:10644282957

SN - 0039-7911

VL - 34

SP - 4285

EP - 4291

JO - Synthetic Communications

JF - Synthetic Communications

IS - 23

ER -

New method for the synthesis of 5-hydroxycamptothecin derivatives

摘要

访问文件

其它文件与链接

学术指纹

引用此