Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

Lan Yang; Yanpeng Zhu; Aijing Ma; Wei Gao; Zhaoyang Guo; Yujia Xin; Ruixue Ran; Xiaoying Yang

doi:10.1016/j.jphotochem.2022.114341

Near-infrared laser/H₂O₂ dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

Lan Yang
, Yanpeng Zhu
, Aijing Ma
, Wei Gao
, Zhaoyang Guo
, Yujia Xin
, Ruixue Ran^*
, Xiaoying Yang

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re₂(CO)₁₀ and ultra-small Cu_2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H₂O₂ enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

源语言	英语
文章编号	114341
期刊	Journal of Photochemistry and Photobiology A: Chemistry
卷	435
DOI	https://doi.org/10.1016/j.jphotochem.2022.114341
出版状态	已出版 - 1 2月 2023
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1016/j.jphotochem.2022.114341

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引用此

@article{0bab2dd9e88e432ebd82f6a7e792dd83,

title = "Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy",

abstract = "The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.",

keywords = "Chemodynamic therapy, CO therapy, Mesoporous polydopamine nanoparticles, Photothermal therapy, Tumor combination therapy",

author = "Lan Yang and Yanpeng Zhu and Aijing Ma and Wei Gao and Zhaoyang Guo and Yujia Xin and Ruixue Ran and Xiaoying Yang",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = feb,

day = "1",

doi = "10.1016/j.jphotochem.2022.114341",

language = "英语",

volume = "435",

journal = "Journal of Photochemistry and Photobiology A: Chemistry",

issn = "1010-6030",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

AU - Yang, Lan

AU - Zhu, Yanpeng

AU - Ma, Aijing

AU - Gao, Wei

AU - Guo, Zhaoyang

AU - Xin, Yujia

AU - Ran, Ruixue

AU - Yang, Xiaoying

PY - 2023/2/1

Y1 - 2023/2/1

N2 - The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

AB - The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

KW - Chemodynamic therapy

KW - CO therapy

KW - Mesoporous polydopamine nanoparticles

KW - Photothermal therapy

KW - Tumor combination therapy

UR - https://www.scopus.com/pages/publications/85139841945

U2 - 10.1016/j.jphotochem.2022.114341

DO - 10.1016/j.jphotochem.2022.114341

M3 - 文章

AN - SCOPUS:85139841945

SN - 1010-6030

VL - 435

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

M1 - 114341

ER -

Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

摘要

联合国可持续发展目标

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引用此

Near-infrared laser/H₂O₂ dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy