N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

Xuhong Qian; Wei Yao; Gang Chen; Xiayu Huang; Ping Mao

doi:10.1016/S0040-4039(01)01214-X

N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

Xuhong Qian^*
, Wei Yao
, Gang Chen
, Xiayu Huang
, Ping Mao

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

15 引用（Scopus）

摘要

A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

源语言	英语
页（从-至）	6175-6178
页数	4
期刊	Tetrahedron Letters
卷	42
期	35
DOI	https://doi.org/10.1016/S0040-4039(01)01214-X
出版状态	已出版 - 27 8月 2001
已对外发布	是

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title = "N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects",

abstract = "A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.",

author = "Xuhong Qian and Wei Yao and Gang Chen and Xiayu Huang and Ping Mao",

year = "2001",

month = aug,

day = "27",

doi = "10.1016/S0040-4039(01)01214-X",

language = "英语",

volume = "42",

pages = "6175--6178",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers

T2 - Substituent effects

AU - Qian, Xuhong

AU - Yao, Wei

AU - Chen, Gang

AU - Huang, Xiayu

AU - Mao, Ping

PY - 2001/8/27

Y1 - 2001/8/27

N2 - A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

AB - A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

UR - https://www.scopus.com/pages/publications/0035959471

U2 - 10.1016/S0040-4039(01)01214-X

DO - 10.1016/S0040-4039(01)01214-X

M3 - 文章

AN - SCOPUS:0035959471

SN - 0040-4039

VL - 42

SP - 6175

EP - 6178

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

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