Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

Yannan Yang; Yao Lu; Prasanna Lakshmi Abbaraju; Jun Zhang; Min Zhang; Guangya Xiang; Chengzhong Yu

doi:10.1002/anie.201701550

Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

Yannan Yang
, Yao Lu
, Prasanna Lakshmi Abbaraju
, Jun Zhang
, Min Zhang
, Guangya Xiang^*
, Chengzhong Yu

^*此作品的通讯作者

University of Queensland
Huazhong University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

146 引用（Scopus）

摘要

Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

源语言	英语
页（从-至）	8446-8450
页数	5
期刊	Angewandte Chemie - International Edition
卷	56
期	29
DOI	https://doi.org/10.1002/anie.201701550
出版状态	已出版 - 10 7月 2017
已对外发布	是

联合国可持续发展目标

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title = "Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy",

abstract = "Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.",

keywords = "adjuvants, antitumor activity, immunotherapy, multi-shelled materials, organosilica",

author = "Yannan Yang and Yao Lu and Abbaraju, \{Prasanna Lakshmi\} and Jun Zhang and Min Zhang and Guangya Xiang and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = jul,

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doi = "10.1002/anie.201701550",

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AU - Yang, Yannan

AU - Lu, Yao

AU - Abbaraju, Prasanna Lakshmi

AU - Zhang, Jun

AU - Zhang, Min

AU - Xiang, Guangya

AU - Yu, Chengzhong

PY - 2017/7/10

Y1 - 2017/7/10

N2 - Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

AB - Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

KW - adjuvants

KW - antitumor activity

KW - immunotherapy

KW - multi-shelled materials

KW - organosilica

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DO - 10.1002/anie.201701550

M3 - 文章

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AN - SCOPUS:85019004897

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 29

ER -

Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

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