TY - JOUR
T1 - Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides
AU - Li, Feng
AU - Cui, Jingnan
AU - Guo, Lianying
AU - Qian, Xuhong
AU - Ren, Weimin
AU - Wang, Kewei
AU - Liu, Fengyu
PY - 2007/8/1
Y1 - 2007/8/1
N2 - A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.
AB - A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.
KW - '4-1' Pentacyclic DNA-intercalating agents
KW - Aryl/heteroaryl-imidazonaphthalimides
UR - https://www.scopus.com/pages/publications/34249939072
U2 - 10.1016/j.bmc.2007.05.032
DO - 10.1016/j.bmc.2007.05.032
M3 - 文章
C2 - 17532640
AN - SCOPUS:34249939072
SN - 0968-0896
VL - 15
SP - 5114
EP - 5121
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 15
ER -