Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

Ming Li; Jia Hui Huang; Bo Zhang; Kai Hong

doi:10.1021/acs.joc.6c00309

Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

Ming Li
, Jia Hui Huang
, Bo Zhang
, Kai Hong^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.

源语言	英语
页（从-至）	4521-4527
页数	7
期刊	Journal of Organic Chemistry
卷	91
期	12
DOI	https://doi.org/10.1021/acs.joc.6c00309
出版状态	已出版 - 27 3月 2026

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10.1021/acs.joc.6c00309

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abstract = "Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.",

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AU - Hong, Kai

PY - 2026/3/27

Y1 - 2026/3/27

N2 - Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.

AB - Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.

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Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

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