@article{75aa2658f7814329b28052ec4bc8307f,
title = "Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity",
abstract = "Zhu et al. report that CRISPR editing displaces CTCF- and condensate-associated distal regulations, rewiring 3D genomic regulation. Even distal cleavage causes stem cell differentiation. The authors propose strategies to minimize chromatin disruption and preserve cell identity.",
keywords = "chromatin architecture, chromatin condensate, chromatin perturbation, genome editing, neural stem cell, premature differentiation, somatic stem cell",
author = "Ming Zhu and Junsong Yuan and Qiuchen Meng and Jiawei Yu and Xiaoqing Xu and Mingyue Xu and Xiaoyu Ren and Yanyan Hu and Guoan Wei and Zeran Jia and Guohua Yuan and Lu Zang and Shaorui Liu and Yuanyuan Yang and Yuan Zheng and Jiacheng Wang and Tingting Cong and Wei Xie and Xun Lan and Le Cong and Tianhua Ma and Sheng Ding and Weixiang Guo and Xuegong Zhang and Yinqing Li",
note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",
year = "2026",
month = mar,
day = "5",
doi = "10.1016/j.stem.2026.01.015",
language = "英语",
volume = "33",
pages = "470--486.e14",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "3",
}