Methylene C(sp3)-H arylation of aliphatic ketones using a transient directing group

Kai Hong; Hojoon Park; Jin Quan Yu

doi:10.1021/acscatal.7b02905

Methylene C(sp³)-H arylation of aliphatic ketones using a transient directing group

Kai Hong
, Hojoon Park
, Jin Quan Yu^*

^*此作品的通讯作者

Scripps Research Institute

科研成果: 期刊稿件 › 文章 › 同行评审

99 引用（Scopus）

摘要

Palladium-catalyzed methylene β-C(sp³)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp³)-H bond activation.

源语言	英语
页（从-至）	6938-6941
页数	4
期刊	ACS Catalysis
卷	7
期	10
DOI	https://doi.org/10.1021/acscatal.7b02905
出版状态	已出版 - 6 10月 2017
已对外发布	是

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10.1021/acscatal.7b02905

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title = "Methylene C(sp3)-H arylation of aliphatic ketones using a transient directing group",

abstract = "Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.",

keywords = "Arylation, C-H activation, Ketone, Palladium, Transient directing group, β-amino acid",

author = "Kai Hong and Hojoon Park and Yu, \{Jin Quan\}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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doi = "10.1021/acscatal.7b02905",

language = "英语",

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T1 - Methylene C(sp3)-H arylation of aliphatic ketones using a transient directing group

AU - Hong, Kai

AU - Park, Hojoon

AU - Yu, Jin Quan

PY - 2017/10/6

Y1 - 2017/10/6

N2 - Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.

AB - Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.

KW - Arylation

KW - C-H activation

KW - Ketone

KW - Palladium

KW - Transient directing group

KW - β-amino acid

UR - https://www.scopus.com/pages/publications/85032729748

U2 - 10.1021/acscatal.7b02905

DO - 10.1021/acscatal.7b02905

M3 - 文章

AN - SCOPUS:85032729748

SN - 2155-5435

VL - 7

SP - 6938

EP - 6941

JO - ACS Catalysis

JF - ACS Catalysis

IS - 10

ER -

Methylene C(sp3)-H arylation of aliphatic ketones using a transient directing group

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Methylene C(sp³)-H arylation of aliphatic ketones using a transient directing group