Metal-free tandem Friedel-Crafts/lactonization reaction to benzofuranones bearing a quaternary center at C3 position

Long Chen; Feng Zhou; Tao Da Shi; Jian Zhou

doi:10.1021/jo300395x

Metal-free tandem Friedel-Crafts/lactonization reaction to benzofuranones bearing a quaternary center at C3 position

Long Chen
, Feng Zhou
, Tao Da Shi
, Jian Zhou^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

59 引用（Scopus）

摘要

A metal-free tandem Friedel-Crafts/lactonization reaction to 3,3-diaryl or 3-alkyl-3-aryl benzofuranones catalyzed by HClO ₄ was reported. A variety of tertiary α-hydroxy acid esters could readily react with substituted phenols to afford the desired products in rich diversity. The synthetic utility of the products was demonstrated by the synthesis of polycyclic compounds. ¹H NMR studies supported that this tandem reaction proceeded via tandem Friedel-Crafts/lactonization sequence.

源语言	英语
页（从-至）	4354-4362
页数	9
期刊	Journal of Organic Chemistry
卷	77
期	9
DOI	https://doi.org/10.1021/jo300395x
出版状态	已出版 - 4 5月 2012

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abstract = "A metal-free tandem Friedel-Crafts/lactonization reaction to 3,3-diaryl or 3-alkyl-3-aryl benzofuranones catalyzed by HClO 4 was reported. A variety of tertiary α-hydroxy acid esters could readily react with substituted phenols to afford the desired products in rich diversity. The synthetic utility of the products was demonstrated by the synthesis of polycyclic compounds. 1H NMR studies supported that this tandem reaction proceeded via tandem Friedel-Crafts/lactonization sequence.",

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AU - Chen, Long

AU - Zhou, Feng

AU - Shi, Tao Da

AU - Zhou, Jian

PY - 2012/5/4

Y1 - 2012/5/4

N2 - A metal-free tandem Friedel-Crafts/lactonization reaction to 3,3-diaryl or 3-alkyl-3-aryl benzofuranones catalyzed by HClO 4 was reported. A variety of tertiary α-hydroxy acid esters could readily react with substituted phenols to afford the desired products in rich diversity. The synthetic utility of the products was demonstrated by the synthesis of polycyclic compounds. 1H NMR studies supported that this tandem reaction proceeded via tandem Friedel-Crafts/lactonization sequence.

AB - A metal-free tandem Friedel-Crafts/lactonization reaction to 3,3-diaryl or 3-alkyl-3-aryl benzofuranones catalyzed by HClO 4 was reported. A variety of tertiary α-hydroxy acid esters could readily react with substituted phenols to afford the desired products in rich diversity. The synthetic utility of the products was demonstrated by the synthesis of polycyclic compounds. 1H NMR studies supported that this tandem reaction proceeded via tandem Friedel-Crafts/lactonization sequence.

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M3 - 文章

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JF - Journal of Organic Chemistry

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ER -

Metal-free tandem Friedel-Crafts/lactonization reaction to benzofuranones bearing a quaternary center at C3 position

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