Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Chang Lei; Chun Xu; Owen Noonan; Anand Kumar Meka; Long Zhang; Amanda Nouwens; Chengzhong Yu

doi:10.1039/c5cc04458h

Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Chang Lei
, Chun Xu
, Owen Noonan
, Anand Kumar Meka
, Long Zhang
, Amanda Nouwens
, Chengzhong Yu^*

^*此作品的通讯作者

University of Queensland

科研成果: 期刊稿件 › 文章 › 同行评审

15 引用（Scopus）

摘要

A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml^-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

源语言	英语
页（从-至）	13642-13645
页数	4
期刊	Chemical Communications
卷	51
期	71
DOI	https://doi.org/10.1039/c5cc04458h
出版状态	已出版 - 17 7月 2015
已对外发布	是

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abstract = "A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.",

author = "Chang Lei and Chun Xu and Owen Noonan and Meka, \{Anand Kumar\} and Long Zhang and Amanda Nouwens and Chengzhong Yu",

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AU - Lei, Chang

AU - Xu, Chun

AU - Noonan, Owen

AU - Meka, Anand Kumar

AU - Zhang, Long

AU - Nouwens, Amanda

AU - Yu, Chengzhong

PY - 2015/7/17

Y1 - 2015/7/17

N2 - A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

AB - A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

UR - https://www.scopus.com/pages/publications/84939863816

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DO - 10.1039/c5cc04458h

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Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

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