TY - JOUR
T1 - Lipid Nanocarrier-Based mRNA Therapy
T2 - Challenges and Promise for Clinical Transformation
AU - Li, Wenchao
AU - Wang, Chen
AU - Zhang, Yifei
AU - Lu, Yuan
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/7/11
Y1 - 2024/7/11
N2 - Due to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carriers for mRNA delivery due to their high delivery efficiency, few side effects, and easy modification to change their structures and functions. To achieve the desired biological effect, lipid nanocarriers must reach the designated location for effective drug delivery. Therefore, the effects of the composition of lipid nanocarriers on their key properties are briefly reviewed. In addition, the progress of smart drug delivery by changing the composition of lipid nanocarriers is summarized, and the importance of component design and structure is emphasized. Subsequently, this review summarizes the latest progress in lipid nanocarrier-based mRNA technology and provides corresponding strategies for its current challenges, putting forward valuable information for the future design of lipid nanocarriers and mRNA.
AB - Due to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carriers for mRNA delivery due to their high delivery efficiency, few side effects, and easy modification to change their structures and functions. To achieve the desired biological effect, lipid nanocarriers must reach the designated location for effective drug delivery. Therefore, the effects of the composition of lipid nanocarriers on their key properties are briefly reviewed. In addition, the progress of smart drug delivery by changing the composition of lipid nanocarriers is summarized, and the importance of component design and structure is emphasized. Subsequently, this review summarizes the latest progress in lipid nanocarrier-based mRNA technology and provides corresponding strategies for its current challenges, putting forward valuable information for the future design of lipid nanocarriers and mRNA.
KW - clinical transformation
KW - lipid composition
KW - lipid nanocarrier
KW - mRNA delivery
UR - https://www.scopus.com/pages/publications/85183423024
U2 - 10.1002/smll.202310531
DO - 10.1002/smll.202310531
M3 - 文献综述
C2 - 38287729
AN - SCOPUS:85183423024
SN - 1613-6810
VL - 20
JO - Small
JF - Small
IS - 28
M1 - 2310531
ER -