Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

Zilong Pan; Luhua Liu; Senmiao Xu; Zhenlu Shen

doi:10.1039/d0ra10211c

Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

Zilong Pan
, Luhua Liu
, Senmiao Xu^*
, Zhenlu Shen

^*此作品的通讯作者

Zhejiang University of Technology
CAS - Lanzhou Institute of Chemical Physics
University of Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

源语言	英语
页（从-至）	5487-5490
页数	4
期刊	RSC Advances
卷	11
期	10
DOI	https://doi.org/10.1039/d0ra10211c
出版状态	已出版 - 29 1月 2021
已对外发布	是

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abstract = "We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.",

author = "Zilong Pan and Luhua Liu and Senmiao Xu and Zhenlu Shen",

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T1 - Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

AU - Pan, Zilong

AU - Liu, Luhua

AU - Xu, Senmiao

AU - Shen, Zhenlu

PY - 2021/1/29

Y1 - 2021/1/29

N2 - We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

AB - We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

UR - https://www.scopus.com/pages/publications/85100515368

U2 - 10.1039/d0ra10211c

DO - 10.1039/d0ra10211c

M3 - 文章

AN - SCOPUS:85100515368

SN - 2046-2069

VL - 11

SP - 5487

EP - 5490

JO - RSC Advances

JF - RSC Advances

IS - 10

ER -

Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

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