Ligand-Controlled Regiodivergent Alkoxycarbonylation of Trifluoromethylthiolated Internal Alkynes

Bin Wang; Chaoren Shen; Kaiwu Dong

doi:10.1021/acs.orglett.4c01113

Ligand-Controlled Regiodivergent Alkoxycarbonylation of Trifluoromethylthiolated Internal Alkynes

Bin Wang
, Chaoren Shen
, Kaiwu Dong^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

5 引用（Scopus）

摘要

Controlling the regioselectivity for the alkoxycarbonylation of unsymmetric internal alkynes is challenging. Herein, a palladium-catalyzed ligand-controlled regiodivergent alkoxycarbonylation of internal trifluoromethylthiolated alkynes was achieved. A series of α- or β-SCF₃ acrylates from the same trifluoromethylthiolated alkyne were obtained with moderate to high yield and regioselectivity.

源语言	英语
页（从-至）	3628-3633
页数	6
期刊	Organic Letters
卷	26
期	17
DOI	https://doi.org/10.1021/acs.orglett.4c01113
出版状态	已出版 - 3 5月 2024

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title = "Ligand-Controlled Regiodivergent Alkoxycarbonylation of Trifluoromethylthiolated Internal Alkynes",

abstract = "Controlling the regioselectivity for the alkoxycarbonylation of unsymmetric internal alkynes is challenging. Herein, a palladium-catalyzed ligand-controlled regiodivergent alkoxycarbonylation of internal trifluoromethylthiolated alkynes was achieved. A series of α- or β-SCF3 acrylates from the same trifluoromethylthiolated alkyne were obtained with moderate to high yield and regioselectivity.",

author = "Bin Wang and Chaoren Shen and Kaiwu Dong",

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T1 - Ligand-Controlled Regiodivergent Alkoxycarbonylation of Trifluoromethylthiolated Internal Alkynes

AU - Wang, Bin

AU - Shen, Chaoren

AU - Dong, Kaiwu

PY - 2024/5/3

Y1 - 2024/5/3

N2 - Controlling the regioselectivity for the alkoxycarbonylation of unsymmetric internal alkynes is challenging. Herein, a palladium-catalyzed ligand-controlled regiodivergent alkoxycarbonylation of internal trifluoromethylthiolated alkynes was achieved. A series of α- or β-SCF3 acrylates from the same trifluoromethylthiolated alkyne were obtained with moderate to high yield and regioselectivity.

AB - Controlling the regioselectivity for the alkoxycarbonylation of unsymmetric internal alkynes is challenging. Herein, a palladium-catalyzed ligand-controlled regiodivergent alkoxycarbonylation of internal trifluoromethylthiolated alkynes was achieved. A series of α- or β-SCF3 acrylates from the same trifluoromethylthiolated alkyne were obtained with moderate to high yield and regioselectivity.

UR - https://www.scopus.com/pages/publications/85191945349

U2 - 10.1021/acs.orglett.4c01113

DO - 10.1021/acs.orglett.4c01113

M3 - 文章

C2 - 38652586

AN - SCOPUS:85191945349

SN - 1523-7060

VL - 26

SP - 3628

EP - 3633

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Ligand-Controlled Regiodivergent Alkoxycarbonylation of Trifluoromethylthiolated Internal Alkynes

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