Latent Feature Regularization based Adversarial Network for Brain Tumor Anomaly Detection

Brain tumor anomaly detection plays a critical role in the field of computer-aided diagnosis, which has attracted ever-increasing focus from the medical community However, brain tumor data are scarce and tough to classify. Unsupervised methods enable the reduction of huge labeling costs to be applied to brain tumor anomaly detection during the training only given normal brain images. However, the existing unsupervised methods distinguish whether the input image is abnormal in the image space, which cannot effectively learn the discriminative features. In this paper, we propose a novel brain tumor anomaly detection method via Latent Feature Regularization based Adversarial Network (LFRA-Net), which leverages a latent feature regularizer into adversarial learning to obtain the discriminative features. Comprehensive experiments on BraTS, HCP, MNIST, and CIFAR-10 datasets evaluate the effectiveness of our LFRANet, which outperforms state-of-the-art unsupervised learning methods.