Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

Caroline Gluck; Chengxiang Qiu; Sang Youb Han; Matthew Palmer; Jihwan Park; Yi An Ko; Yuting Guan; Xin Sheng; Robert L. Hanson; Jing Huang; Yong Chen; Ae Seo Deok Park; Maria Concepcion Izquierdo; Ioannis Mantzaris; Amit Verma; James Pullman; Hongzhe Li; Katalin Susztak

doi:10.1038/s41467-019-10378-8

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

Caroline Gluck
, Chengxiang Qiu
, Sang Youb Han
, Matthew Palmer
, Jihwan Park
, Yi An Ko
, Yuting Guan
, Xin Sheng
, Robert L. Hanson
, Jing Huang
, Yong Chen
, Ae Seo Deok Park
, Maria Concepcion Izquierdo
, Ioannis Mantzaris
, Amit Verma
, James Pullman
, Hongzhe Li
, Katalin Susztak^*

^*此作品的通讯作者

University of Pennsylvania
Center for Violence Prevention at Children’s Hospital of Philadelphia
Inje University
National Institutes of Health
Albert Einstein College of Medicine

科研成果: 期刊稿件 › 文章 › 同行评审

73 引用（Scopus）

摘要

Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We find that the methylation levels of 65 probes are associated with the degree of kidney fibrosis at genome wide significance. In total 471 probes improve the model for kidney function decline. Methylation probes associated with kidney damage and functional decline enrich on kidney regulatory regions and associate with gene expression changes, including epidermal growth factor (EGF). Altogether, our work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.

源语言	英语
文章编号	2461
期刊	Nature Communications
卷	10
期	1
DOI	https://doi.org/10.1038/s41467-019-10378-8
出版状态	已出版 - 1 12月 2019
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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Gluck, C., Qiu, C., Han, S. Y., Palmer, M., Park, J., Ko, Y. A., Guan, Y., Sheng, X., Hanson, R. L., Huang, J., Chen, Y., Park, A. S. D., Izquierdo, M. C., Mantzaris, I., Verma, A., Pullman, J., Li, H., & Susztak, K. (2019). Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease. Nature Communications, 10(1), 文章 2461. https://doi.org/10.1038/s41467-019-10378-8

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title = "Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease",

abstract = "Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We find that the methylation levels of 65 probes are associated with the degree of kidney fibrosis at genome wide significance. In total 471 probes improve the model for kidney function decline. Methylation probes associated with kidney damage and functional decline enrich on kidney regulatory regions and associate with gene expression changes, including epidermal growth factor (EGF). Altogether, our work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.",

author = "Caroline Gluck and Chengxiang Qiu and Han, \{Sang Youb\} and Matthew Palmer and Jihwan Park and Ko, \{Yi An\} and Yuting Guan and Xin Sheng and Hanson, \{Robert L.\} and Jing Huang and Yong Chen and Park, \{Ae Seo Deok\} and Izquierdo, \{Maria Concepcion\} and Ioannis Mantzaris and Amit Verma and James Pullman and Hongzhe Li and Katalin Susztak",

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doi = "10.1038/s41467-019-10378-8",

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Gluck, C, Qiu, C, Han, SY, Palmer, M, Park, J, Ko, YA, Guan, Y, Sheng, X, Hanson, RL, Huang, J, Chen, Y, Park, ASD, Izquierdo, MC, Mantzaris, I, Verma, A, Pullman, J, Li, H & Susztak, K 2019, 'Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease', Nature Communications, 卷 10, 号码 1, 2461. https://doi.org/10.1038/s41467-019-10378-8

TY - JOUR

T1 - Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

AU - Gluck, Caroline

AU - Qiu, Chengxiang

AU - Han, Sang Youb

AU - Palmer, Matthew

AU - Park, Jihwan

AU - Ko, Yi An

AU - Guan, Yuting

AU - Sheng, Xin

AU - Hanson, Robert L.

AU - Huang, Jing

AU - Chen, Yong

AU - Park, Ae Seo Deok

AU - Izquierdo, Maria Concepcion

AU - Mantzaris, Ioannis

AU - Verma, Amit

AU - Pullman, James

AU - Li, Hongzhe

AU - Susztak, Katalin

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We find that the methylation levels of 65 probes are associated with the degree of kidney fibrosis at genome wide significance. In total 471 probes improve the model for kidney function decline. Methylation probes associated with kidney damage and functional decline enrich on kidney regulatory regions and associate with gene expression changes, including epidermal growth factor (EGF). Altogether, our work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.

AB - Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We find that the methylation levels of 65 probes are associated with the degree of kidney fibrosis at genome wide significance. In total 471 probes improve the model for kidney function decline. Methylation probes associated with kidney damage and functional decline enrich on kidney regulatory regions and associate with gene expression changes, including epidermal growth factor (EGF). Altogether, our work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.

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SN - 2041-1723

VL - 10

JO - Nature Communications

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ER -

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

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