Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia

Chaoqun Ma; Jianghui Chen; Dong Xing; Yuan Sheng; Wenhao Hu

doi:10.1039/c7cc00003k

Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia

Chaoqun Ma
, Jianghui Chen
, Dong Xing
, Yuan Sheng
, Wenhao Hu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

17 引用（Scopus）

摘要

An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62 : 38 dr.

源语言	英语
页（从-至）	2854-2857
页数	4
期刊	Chemical Communications
卷	53
期	19
DOI	https://doi.org/10.1039/c7cc00003k
出版状态	已出版 - 2017

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10.1039/c7cc00003k

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abstract = "An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77\% yield and 62 : 38 dr.",

author = "Chaoqun Ma and Jianghui Chen and Dong Xing and Yuan Sheng and Wenhao Hu",

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T1 - Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia

AU - Ma, Chaoqun

AU - Chen, Jianghui

AU - Xing, Dong

AU - Sheng, Yuan

AU - Hu, Wenhao

PY - 2017

Y1 - 2017

N2 - An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62 : 38 dr.

AB - An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62 : 38 dr.

UR - https://www.scopus.com/pages/publications/85014393654

U2 - 10.1039/c7cc00003k

DO - 10.1039/c7cc00003k

M3 - 文章

C2 - 28217767

AN - SCOPUS:85014393654

SN - 1359-7345

VL - 53

SP - 2854

EP - 2857

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia

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