Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: A Michael addition-cyclization approach to 3-carbonyl quinolines

Hongfeng Li; Xiaolei Xu; Jingyu Yang; Xin Xie; He Huang; Yanzhong Li

doi:10.1016/j.tetlet.2010.11.106

Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: A Michael addition-cyclization approach to 3-carbonyl quinolines

Hongfeng Li
, Xiaolei Xu
, Jingyu Yang
, Xin Xie
, He Huang
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

50 引用（Scopus）

摘要

An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air.

源语言	英语
页（从-至）	530-533
页数	4
期刊	Tetrahedron Letters
卷	52
期	4
DOI	https://doi.org/10.1016/j.tetlet.2010.11.106
出版状态	已出版 - 26 1月 2011

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title = "Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: A Michael addition-cyclization approach to 3-carbonyl quinolines",

abstract = "An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air.",

keywords = "Cascade reaction, Iron catalysis, Michael addition/cyclization, Quinolines",

author = "Hongfeng Li and Xiaolei Xu and Jingyu Yang and Xin Xie and He Huang and Yanzhong Li",

year = "2011",

month = jan,

day = "26",

doi = "10.1016/j.tetlet.2010.11.106",

language = "英语",

volume = "52",

pages = "530--533",

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TY - JOUR

T1 - Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds

T2 - A Michael addition-cyclization approach to 3-carbonyl quinolines

AU - Li, Hongfeng

AU - Xu, Xiaolei

AU - Yang, Jingyu

AU - Xie, Xin

AU - Huang, He

AU - Li, Yanzhong

PY - 2011/1/26

Y1 - 2011/1/26

N2 - An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air.

AB - An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air.

KW - Cascade reaction

KW - Iron catalysis

KW - Michael addition/cyclization

KW - Quinolines

UR - https://www.scopus.com/pages/publications/78650521271

U2 - 10.1016/j.tetlet.2010.11.106

DO - 10.1016/j.tetlet.2010.11.106

M3 - 文章

AN - SCOPUS:78650521271

SN - 0040-4039

VL - 52

SP - 530

EP - 533

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Iron-catalyzed cascade reaction of ynone with o-aminoaryl compounds: A Michael addition-cyclization approach to 3-carbonyl quinolines

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