Iridium(I)-Catalyzed Atroposelective Alkenylation of Heterobiaryls with Terminal Alkynes

Maoqian Xiong; Feifei Chen; Yuhang Shu; Xiang Wu; Jie Tang; Fan Yang; Dong Xing

doi:10.1021/acs.orglett.3c01453

Iridium(I)-Catalyzed Atroposelective Alkenylation of Heterobiaryls with Terminal Alkynes

Maoqian Xiong
, Feifei Chen
, Yuhang Shu
, Xiang Wu
, Jie Tang
, Fan Yang^*
, Dong Xing^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

7 引用（Scopus）

摘要

Herein we report an iridium(I)-catalyzed atroposelective alkenylation of isoquinoline-derived heterobiaryls with terminal alkynes. In the presence of a cationic iridium(I) catalyst with (R)-SEGPHOS as the chiral ligand, this atom-economical alkenylation protocol allows the rapid construction of a series of axially chiral alkenylated heterobiaryls in moderate to good yields with good to high enantioselectivities.

源语言	英语
页（从-至）	5703-5708
页数	6
期刊	Organic Letters
卷	25
期	31
DOI	https://doi.org/10.1021/acs.orglett.3c01453
出版状态	已出版 - 11 8月 2023

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10.1021/acs.orglett.3c01453

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abstract = "Herein we report an iridium(I)-catalyzed atroposelective alkenylation of isoquinoline-derived heterobiaryls with terminal alkynes. In the presence of a cationic iridium(I) catalyst with (R)-SEGPHOS as the chiral ligand, this atom-economical alkenylation protocol allows the rapid construction of a series of axially chiral alkenylated heterobiaryls in moderate to good yields with good to high enantioselectivities.",

author = "Maoqian Xiong and Feifei Chen and Yuhang Shu and Xiang Wu and Jie Tang and Fan Yang and Dong Xing",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",

year = "2023",

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day = "11",

doi = "10.1021/acs.orglett.3c01453",

language = "英语",

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TY - JOUR

T1 - Iridium(I)-Catalyzed Atroposelective Alkenylation of Heterobiaryls with Terminal Alkynes

AU - Xiong, Maoqian

AU - Chen, Feifei

AU - Shu, Yuhang

AU - Wu, Xiang

AU - Tang, Jie

AU - Yang, Fan

AU - Xing, Dong

PY - 2023/8/11

Y1 - 2023/8/11

N2 - Herein we report an iridium(I)-catalyzed atroposelective alkenylation of isoquinoline-derived heterobiaryls with terminal alkynes. In the presence of a cationic iridium(I) catalyst with (R)-SEGPHOS as the chiral ligand, this atom-economical alkenylation protocol allows the rapid construction of a series of axially chiral alkenylated heterobiaryls in moderate to good yields with good to high enantioselectivities.

AB - Herein we report an iridium(I)-catalyzed atroposelective alkenylation of isoquinoline-derived heterobiaryls with terminal alkynes. In the presence of a cationic iridium(I) catalyst with (R)-SEGPHOS as the chiral ligand, this atom-economical alkenylation protocol allows the rapid construction of a series of axially chiral alkenylated heterobiaryls in moderate to good yields with good to high enantioselectivities.

UR - https://www.scopus.com/pages/publications/85167813468

U2 - 10.1021/acs.orglett.3c01453

DO - 10.1021/acs.orglett.3c01453

M3 - 文章

C2 - 37523590

AN - SCOPUS:85167813468

SN - 1523-7060

VL - 25

SP - 5703

EP - 5708

JO - Organic Letters

JF - Organic Letters

IS - 31

ER -

Iridium(I)-Catalyzed Atroposelective Alkenylation of Heterobiaryls with Terminal Alkynes

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