Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

Lili Chen; Yuhuan Yang; Luhua Liu; Qian Gao; Senmiao Xu

doi:10.1021/jacs.0c06756

Iridium-Catalyzed Enantioselective α-C(sp³)-H Borylation of Azacycles

Lili Chen
, Yuhuan Yang
, Luhua Liu
, Qian Gao
, Senmiao Xu^*

^*此作品的通讯作者

CAS - Lanzhou Institute of Chemical Physics
University of Chinese Academy of Sciences
Hangzhou Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

89 引用（Scopus）

摘要

We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

源语言	英语
页（从-至）	12062-12068
页数	7
期刊	Journal of the American Chemical Society
卷	142
期	28
DOI	https://doi.org/10.1021/jacs.0c06756
出版状态	已出版 - 15 7月 2020
已对外发布	是

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abstract = "We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.",

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AU - Chen, Lili

AU - Yang, Yuhuan

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AU - Gao, Qian

AU - Xu, Senmiao

PY - 2020/7/15

Y1 - 2020/7/15

N2 - We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

AB - We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

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JF - Journal of the American Chemical Society

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ER -

Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

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Iridium-Catalyzed Enantioselective α-C(sp³)-H Borylation of Azacycles