Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

Yuanyuan Liu; Wanbin Zhang

doi:10.1002/anie.201209126

Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

Yuanyuan Liu
, Wanbin Zhang^*

^*此作品的通讯作者

Shanghai Jiao Tong University

科研成果: 期刊稿件 › 文章 › 同行评审

105 引用（Scopus）

摘要

Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF ^-=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

源语言	英语
页（从-至）	2203-2206
页数	4
期刊	Angewandte Chemie - International Edition
卷	52
期	8
DOI	https://doi.org/10.1002/anie.201209126
出版状态	已出版 - 18 2月 2013
已对外发布	是

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title = "Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides",

abstract = "Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol \%) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.",

keywords = "asymmetric catalysis, hydrogenation, iridium, ligand effects, synthetic methods",

author = "Yuanyuan Liu and Wanbin Zhang",

year = "2013",

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doi = "10.1002/anie.201209126",

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T1 - Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

AU - Liu, Yuanyuan

AU - Zhang, Wanbin

PY - 2013/2/18

Y1 - 2013/2/18

N2 - Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

AB - Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate.

KW - asymmetric catalysis

KW - hydrogenation

KW - iridium

KW - ligand effects

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/84873910800

U2 - 10.1002/anie.201209126

DO - 10.1002/anie.201209126

M3 - 文章

C2 - 23335151

AN - SCOPUS:84873910800

SN - 1433-7851

VL - 52

SP - 2203

EP - 2206

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 8

ER -

Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

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