Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Haijun Yu; Zhiai Xu; Dangge Wang; Xianzhi Chen; Zhiwen Zhang; Qi Yin; Yaping Li

doi:10.1039/c3py00849e

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Haijun Yu
, Zhiai Xu
, Dangge Wang
, Xianzhi Chen
, Zhiwen Zhang
, Qi Yin
, Yaping Li^*

^*此作品的通讯作者

化学与分子工程学院

CAS - Shanghai Institute of Materia Medica

科研成果: 期刊稿件 › 文章 › 同行评审

59 引用（Scopus）

摘要

Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

源语言	英语
页（从-至）	5052-5055
页数	4
期刊	Polymer Chemistry
卷	4
期	19
DOI	https://doi.org/10.1039/c3py00849e
出版状态	已出版 - 7 10月 2013

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1039/c3py00849e

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链接到 Scopus 的出版物

引用此

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abstract = "Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a {"}silent{"} state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.",

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T1 - Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

AU - Yu, Haijun

AU - Xu, Zhiai

AU - Wang, Dangge

AU - Chen, Xianzhi

AU - Zhang, Zhiwen

AU - Yin, Qi

AU - Li, Yaping

PY - 2013/10/7

Y1 - 2013/10/7

N2 - Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

AB - Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

UR - https://www.scopus.com/pages/publications/84883333936

U2 - 10.1039/c3py00849e

DO - 10.1039/c3py00849e

M3 - 文章

AN - SCOPUS:84883333936

SN - 1759-9954

VL - 4

SP - 5052

EP - 5055

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 19

ER -

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

摘要

联合国可持续发展目标

访问文件

其它文件与链接

指纹

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