Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

Zhi Fu Tao; Xuhong Qian; Mingcai Fan

doi:10.1246/bcsj.72.1571

Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

Zhi Fu Tao^*
, Xuhong Qian
, Mingcai Fan

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

源语言	英语
页（从-至）	1571-1574
页数	4
期刊	Bulletin of the Chemical Society of Japan
卷	72
期	7
DOI	https://doi.org/10.1246/bcsj.72.1571
出版状态	已出版 - 7月 1999
已对外发布	是

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abstract = "A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.",

author = "Tao, \{Zhi Fu\} and Xuhong Qian and Mingcai Fan",

year = "1999",

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doi = "10.1246/bcsj.72.1571",

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AU - Tao, Zhi Fu

AU - Qian, Xuhong

AU - Fan, Mingcai

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N2 - A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

AB - A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

UR - https://www.scopus.com/pages/publications/0032764245

U2 - 10.1246/bcsj.72.1571

DO - 10.1246/bcsj.72.1571

M3 - 文章

AN - SCOPUS:0032764245

SN - 0009-2673

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JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

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ER -

Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

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