Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

Xuhong Qian; Yonggang Li; Yufang Xu; Yan Liu; Baoyuan Qu

doi:10.1016/j.bmcl.2004.02.059

Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

Xuhong Qian^*
, Yonggang Li
, Yufang Xu
, Yan Liu
, Baoyuan Qu

^*此作品的通讯作者

Dalian University of Technology
East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

源语言	英语
页（从-至）	2665-2668
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	14
期	10
DOI	https://doi.org/10.1016/j.bmcl.2004.02.059
出版状态	已出版 - 17 5月 2004
已对外发布	是

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abstract = "Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.",

keywords = "DNA photocleaver heterocycle",

author = "Xuhong Qian and Yonggang Li and Yufang Xu and Yan Liu and Baoyuan Qu",

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T1 - Highly-efficient DNA photocleavers with long wavelength absorptions

T2 - Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

AU - Qian, Xuhong

AU - Li, Yonggang

AU - Xu, Yufang

AU - Liu, Yan

AU - Qu, Baoyuan

PY - 2004/5/17

Y1 - 2004/5/17

N2 - Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

AB - Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

KW - DNA photocleaver heterocycle

UR - https://www.scopus.com/pages/publications/1942502386

U2 - 10.1016/j.bmcl.2004.02.059

DO - 10.1016/j.bmcl.2004.02.059

M3 - 文章

C2 - 15109674

AN - SCOPUS:1942502386

SN - 0960-894X

VL - 14

SP - 2665

EP - 2668

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

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