Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives

Yongfeng Li; Zhiqiong Tang; Junliang Zhang; Lu Liu

doi:10.1039/d0cc01118e

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp²)-H functionalization and dearomatization of phenol derivatives

Yongfeng Li
, Zhiqiong Tang
, Junliang Zhang
, Lu Liu

化学与分子工程学院

East China Normal University
Fudan University

科研成果: 期刊稿件 › 文章 › 同行评审

35 引用（Scopus）

摘要

Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

源语言	英语
页（从-至）	8202-8205
页数	4
期刊	Chemical Communications
卷	56
期	59
DOI	https://doi.org/10.1039/d0cc01118e
出版状态	已出版 - 28 7月 2020

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10.1039/d0cc01118e

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abstract = "Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.",

author = "Yongfeng Li and Zhiqiong Tang and Junliang Zhang and Lu Liu",

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AU - Li, Yongfeng

AU - Tang, Zhiqiong

AU - Zhang, Junliang

AU - Liu, Lu

PY - 2020/7/28

Y1 - 2020/7/28

N2 - Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

AB - Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

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ER -

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives

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Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp²)-H functionalization and dearomatization of phenol derivatives