TY - JOUR
T1 - Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance
AU - Liu, Chunchen
AU - Li, Mengfei
AU - Ma, Huilong
AU - Hu, Zhubin
AU - Wang, Xinyuan
AU - Ma, Rui
AU - Jiang, Yingying
AU - Sun, Haitao
AU - Zhu, Shoujun
AU - Liang, Yongye
N1 - Publisher Copyright:
© 2023 Chunchen Li et al.
PY - 2023
Y1 - 2023
N2 - The second near-infrared (NIR-II, 1,000 to 1,700 nm) molecular fluorophores containing donor-acceptor- donor conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red shift of absorption, enhanced absorption coefficient, and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LN surgery in tumor-bearing mice. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.
AB - The second near-infrared (NIR-II, 1,000 to 1,700 nm) molecular fluorophores containing donor-acceptor- donor conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red shift of absorption, enhanced absorption coefficient, and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LN surgery in tumor-bearing mice. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.
UR - https://www.scopus.com/pages/publications/85153894605
U2 - 10.34133/research.0039
DO - 10.34133/research.0039
M3 - 文章
AN - SCOPUS:85153894605
SN - 2096-5168
VL - 6
JO - Research
JF - Research
M1 - 0039
ER -