Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Yi Liu; Qingli Wang; Yaozhu Wei; Ying Wu Lin; Wei Li; Ji Hu Su; Zhen Wang; Yang Tian; Zhong Xian Huang; Xiangshi Tan

doi:10.1039/c2cc38224e

Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Yi Liu
, Qingli Wang
, Yaozhu Wei
, Ying Wu Lin
, Wei Li
, Ji Hu Su
, Zhen Wang
, Yang Tian
, Zhong Xian Huang
, Xiangshi Tan^*

^*此作品的通讯作者

Fudan University
Shandong Normal University
University of South China
University of Science and Technology of China
Tongji University

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O₂?⁻ disproportionation, and exhibit impressive Ni-SOD activity.

源语言	英语
页（从-至）	1452-1454
页数	3
期刊	Chemical Communications
卷	49
期	14
DOI	https://doi.org/10.1039/c2cc38224e
出版状态	已出版 - 22 1月 2013
已对外发布	是

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abstract = "Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.",

author = "Yi Liu and Qingli Wang and Yaozhu Wei and Lin, \{Ying Wu\} and Wei Li and Su, \{Ji Hu\} and Zhen Wang and Yang Tian and Huang, \{Zhong Xian\} and Xiangshi Tan",

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T2 - From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

AU - Liu, Yi

AU - Wang, Qingli

AU - Wei, Yaozhu

AU - Lin, Ying Wu

AU - Li, Wei

AU - Su, Ji Hu

AU - Wang, Zhen

AU - Tian, Yang

AU - Huang, Zhong Xian

AU - Tan, Xiangshi

PY - 2013/1/22

Y1 - 2013/1/22

N2 - Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.

AB - Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.

UR - https://www.scopus.com/pages/publications/84872703148

U2 - 10.1039/c2cc38224e

DO - 10.1039/c2cc38224e

M3 - 文章

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AN - SCOPUS:84872703148

SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

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