Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Mingming Hu; Jiangli Fan; Honglin Li; Kedong Song; Song Wang; Guanghui Cheng; Xiaojun Peng

doi:10.1039/c0ob00957a

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Mingming Hu
, Jiangli Fan^*
, Honglin Li
, Kedong Song
, Song Wang
, Guanghui Cheng
, Xiaojun Peng

^*此作品的通讯作者

Dalian University of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

126 引用（Scopus）

摘要

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by ¹H NMR, mass spectrometry analysis and Gaussian calculations.

源语言	英语
页（从-至）	980-983
页数	4
期刊	Organic and Biomolecular Chemistry
卷	9
期	4
DOI	https://doi.org/10.1039/c0ob00957a
出版状态	已出版 - 21 2月 2011
已对外发布	是

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abstract = "A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.",

author = "Mingming Hu and Jiangli Fan and Honglin Li and Kedong Song and Song Wang and Guanghui Cheng and Xiaojun Peng",

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T1 - Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

AU - Hu, Mingming

AU - Fan, Jiangli

AU - Li, Honglin

AU - Song, Kedong

AU - Wang, Song

AU - Cheng, Guanghui

AU - Peng, Xiaojun

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

AB - A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

UR - https://www.scopus.com/pages/publications/79551655318

U2 - 10.1039/c0ob00957a

DO - 10.1039/c0ob00957a

M3 - 文章

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AN - SCOPUS:79551655318

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 4

ER -

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

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