Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

Yufang Xu; Baoyuan Qu; Xuhong Qian; Yonggang Li

doi:10.1016/j.bmcl.2004.12.011

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

Yufang Xu
, Baoyuan Qu
, Xuhong Qian^*
, Yonggang Li

^*此作品的通讯作者

East China University of Science and Technology
Dalian University of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

51 引用（Scopus）

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Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

源语言	英语
页（从-至）	1139-1142
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	15
期	4
DOI	https://doi.org/10.1016/j.bmcl.2004.12.011
出版状态	已出版 - 15 2月 2005
已对外发布	是

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abstract = "Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.",

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T1 - Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains

T2 - Intercalation and photocleavage to DNA

AU - Xu, Yufang

AU - Qu, Baoyuan

AU - Qian, Xuhong

AU - Li, Yonggang

PY - 2005/2/15

Y1 - 2005/2/15

N2 - Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

AB - Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

KW - Five-member

KW - Intercalation

KW - Photocleavage

KW - Thio-heterocyclic fused naphthalimide

UR - https://www.scopus.com/pages/publications/16244392102

U2 - 10.1016/j.bmcl.2004.12.011

DO - 10.1016/j.bmcl.2004.12.011

M3 - 文章

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AN - SCOPUS:16244392102

SN - 0960-894X

VL - 15

SP - 1139

EP - 1142

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

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