Ferrocene Derivatives Modified MOFs-Based Sensors for Electrochemical Detection of Chloramphenicol

Although chloramphenicol(CAP) plays a critical role in many medical treatments, its abuse is not only seriously toxic to humans but also ecologically harmful when discharged into the water. Therefore, it is of great significance to realize the rapid and efficient detection of CAP. 2D MOFs Cu₃(HITP)₂ (HITP = 2,3,6,7,10,11-hexaiminotriphenylene) with higher electrical conductivity than conventional MOFs were synthesized using hydrothermal methods. Fc-NH₂, as an electron donor, was dispersed on the surface of MOFs by physical doping. The synthesized nanocomposite Cu₃(HITP)₂/Fc-NH₂ has excellent adsorption properties and electrical conductivity. It was used to construct an electrochemical sensor and exhibited superior performance in the detection of CAP. Electrochemical reduction of CAP on Cu₃(HITP)₂/Fc-NH₂/GCE was investigated using cyclic voltammetry and differential pulse voltammetry. The results show that Cu₃(HITP)₂/Fc-NH₂/GCE has a much wider linear range of 0.5 ∼ 2100 μm than previous studies when detecting CAP. The detection limit is as low as 0.43 μm. The electrochemical sensing platform reported in this work also exhibits excellent reproducibility, selectivity, and stability, and the recovery rate of CAP detection in the actual sample ranged from 97.1% to 102.4%. This work provides a new strategy for antibiotic detection and extends the application of triphenylene-based MOFs in the electrochemical sensing field.