Fabrication of a micro-optical lens using femtosecond laser 3D micromachining for two-photon imaging of bio-tissues

Lingling Qiao; Fei He; Chen Wang; Yang Liao; Ya Cheng; Koji Sugioka; Katsumi Midorikawa; Change Pan; Xunbin Wei

doi:10.1016/j.optcom.2011.01.082

Fabrication of a micro-optical lens using femtosecond laser 3D micromachining for two-photon imaging of bio-tissues

Lingling Qiao
, Fei He
, Chen Wang
, Yang Liao
, Ya Cheng^*
, Koji Sugioka
, Katsumi Midorikawa
, Change Pan
, Xunbin Wei

^*此作品的通讯作者

CAS - Shanghai Institute of Optics and Fine Mechanics
University of Chinese Academy of Sciences
RIKEN
Fudan University

科研成果: 期刊稿件 › 文章 › 同行评审

20 引用（Scopus）

摘要

We report, for the first time to our knowledge, on the application of a micro-optical lens fabricated by three-dimensional (3D) femtosecond laser direct writing for two-photon fluorescence imaging of biological tissues. We show that the two-photon fluorescence images of a plant leaf tissue acquired with the micro-optical lens are comparable to that of a 5× objective lens. Our result represents an important step towards the application of micro-optical components fabricated by femtosecond laser micromachining in miniaturized nonlinear fluorescence microscopy applications, such as two-photon endoscopy.

源语言	英语
页（从-至）	2988-2991
页数	4
期刊	Optics Communications
卷	284
期	12
DOI	https://doi.org/10.1016/j.optcom.2011.01.082
出版状态	已出版 - 1 6月 2011
已对外发布	是

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title = "Fabrication of a micro-optical lens using femtosecond laser 3D micromachining for two-photon imaging of bio-tissues",

abstract = "We report, for the first time to our knowledge, on the application of a micro-optical lens fabricated by three-dimensional (3D) femtosecond laser direct writing for two-photon fluorescence imaging of biological tissues. We show that the two-photon fluorescence images of a plant leaf tissue acquired with the micro-optical lens are comparable to that of a 5× objective lens. Our result represents an important step towards the application of micro-optical components fabricated by femtosecond laser micromachining in miniaturized nonlinear fluorescence microscopy applications, such as two-photon endoscopy.",

keywords = "Bio-tissue, Femtosecond laser micromachining, Micro-optical lens, Surface roughness, Two-photon imaging",

author = "Lingling Qiao and Fei He and Chen Wang and Yang Liao and Ya Cheng and Koji Sugioka and Katsumi Midorikawa and Change Pan and Xunbin Wei",

year = "2011",

month = jun,

day = "1",

doi = "10.1016/j.optcom.2011.01.082",

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T1 - Fabrication of a micro-optical lens using femtosecond laser 3D micromachining for two-photon imaging of bio-tissues

AU - Qiao, Lingling

AU - He, Fei

AU - Wang, Chen

AU - Liao, Yang

AU - Cheng, Ya

AU - Sugioka, Koji

AU - Midorikawa, Katsumi

AU - Pan, Change

AU - Wei, Xunbin

PY - 2011/6/1

Y1 - 2011/6/1

N2 - We report, for the first time to our knowledge, on the application of a micro-optical lens fabricated by three-dimensional (3D) femtosecond laser direct writing for two-photon fluorescence imaging of biological tissues. We show that the two-photon fluorescence images of a plant leaf tissue acquired with the micro-optical lens are comparable to that of a 5× objective lens. Our result represents an important step towards the application of micro-optical components fabricated by femtosecond laser micromachining in miniaturized nonlinear fluorescence microscopy applications, such as two-photon endoscopy.

AB - We report, for the first time to our knowledge, on the application of a micro-optical lens fabricated by three-dimensional (3D) femtosecond laser direct writing for two-photon fluorescence imaging of biological tissues. We show that the two-photon fluorescence images of a plant leaf tissue acquired with the micro-optical lens are comparable to that of a 5× objective lens. Our result represents an important step towards the application of micro-optical components fabricated by femtosecond laser micromachining in miniaturized nonlinear fluorescence microscopy applications, such as two-photon endoscopy.

KW - Bio-tissue

KW - Femtosecond laser micromachining

KW - Micro-optical lens

KW - Surface roughness

KW - Two-photon imaging

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DO - 10.1016/j.optcom.2011.01.082

M3 - 文章

AN - SCOPUS:79954994381

SN - 0030-4018

VL - 284

SP - 2988

EP - 2991

JO - Optics Communications

JF - Optics Communications

IS - 12

ER -

Fabrication of a micro-optical lens using femtosecond laser 3D micromachining for two-photon imaging of bio-tissues

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