Exploration of 1,3-dipolar cycloaddition reactions to construct the core skeleton of Calyciphylline A-type alkaloids

Jiaxin Zhong; Haibing He; Shuanhu Gao

doi:10.1039/c9qo01111k

Exploration of 1,3-dipolar cycloaddition reactions to construct the core skeleton of Calyciphylline A-type alkaloids

Jiaxin Zhong
, Haibing He^*
, Shuanhu Gao

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

14 引用（Scopus）

摘要

Nitrone induced 1,3-dipolar [3 + 2] cycloadditions were studied to construct the core structure of Calyciphylline A-type Daphniphyllum alkaloids. This approach is capable of installing the cis-hydroindole A-C ring as well as the spiro-A-C-E ring with the all-carbon quaternary centers at C-5 and C-8, and has been successfully used in the total synthesis of himalensine A. It also lays the foundation for the synthesis of challenging Calyciphylline A-type alkaloids, such as daphniyunnine A.

源语言	英语
页（从-至）	3781-3785
页数	5
期刊	Organic Chemistry Frontiers
卷	6
期	22
DOI	https://doi.org/10.1039/c9qo01111k
出版状态	已出版 - 21 11月 2019

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abstract = "Nitrone induced 1,3-dipolar [3 + 2] cycloadditions were studied to construct the core structure of Calyciphylline A-type Daphniphyllum alkaloids. This approach is capable of installing the cis-hydroindole A-C ring as well as the spiro-A-C-E ring with the all-carbon quaternary centers at C-5 and C-8, and has been successfully used in the total synthesis of himalensine A. It also lays the foundation for the synthesis of challenging Calyciphylline A-type alkaloids, such as daphniyunnine A.",

author = "Jiaxin Zhong and Haibing He and Shuanhu Gao",

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doi = "10.1039/c9qo01111k",

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AU - Zhong, Jiaxin

AU - He, Haibing

AU - Gao, Shuanhu

PY - 2019/11/21

Y1 - 2019/11/21

N2 - Nitrone induced 1,3-dipolar [3 + 2] cycloadditions were studied to construct the core structure of Calyciphylline A-type Daphniphyllum alkaloids. This approach is capable of installing the cis-hydroindole A-C ring as well as the spiro-A-C-E ring with the all-carbon quaternary centers at C-5 and C-8, and has been successfully used in the total synthesis of himalensine A. It also lays the foundation for the synthesis of challenging Calyciphylline A-type alkaloids, such as daphniyunnine A.

AB - Nitrone induced 1,3-dipolar [3 + 2] cycloadditions were studied to construct the core structure of Calyciphylline A-type Daphniphyllum alkaloids. This approach is capable of installing the cis-hydroindole A-C ring as well as the spiro-A-C-E ring with the all-carbon quaternary centers at C-5 and C-8, and has been successfully used in the total synthesis of himalensine A. It also lays the foundation for the synthesis of challenging Calyciphylline A-type alkaloids, such as daphniyunnine A.

UR - https://www.scopus.com/pages/publications/85074656510

U2 - 10.1039/c9qo01111k

DO - 10.1039/c9qo01111k

M3 - 文章

AN - SCOPUS:85074656510

SN - 2052-4110

VL - 6

SP - 3781

EP - 3785

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 22

ER -

Exploration of 1,3-dipolar cycloaddition reactions to construct the core skeleton of Calyciphylline A-type alkaloids

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