TY - JOUR
T1 - Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls
AU - Ristow, Inka
AU - Foell, Jens
AU - Kärgel, Christian
AU - Borchardt, Viola
AU - Li, Shijia
AU - Denzel, Dominik
AU - Witzel, Joachim
AU - Drumkova, Krasimira
AU - Beier, Klaus
AU - Kruger, Tillmann H.C.
AU - Ponseti, Jorge
AU - Schiffer, Boris
AU - Schiltz, Kolja
AU - Walter, Henrik
AU - Walter, Martin
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019
Y1 - 2019
N2 - Background: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred)sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation. Methods: Two fMRI studies (1.5 and 7 Tesla)were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls)to assess brain activity during expectancy of subsequent adult (non-preferred)sexual stimuli. In the second study (7 Tesla)additionally child (preferred)cues were presented. Results: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC)activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation. Conclusion: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented.
AB - Background: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred)sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation. Methods: Two fMRI studies (1.5 and 7 Tesla)were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls)to assess brain activity during expectancy of subsequent adult (non-preferred)sexual stimuli. In the second study (7 Tesla)additionally child (preferred)cues were presented. Results: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC)activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation. Conclusion: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented.
KW - Dorsal anterior cingulate cortex (dACC)
KW - Expectancy
KW - Pedophilic disorder
KW - Pedophilic sex offenders
KW - Sexual processing
KW - fMRI
UR - https://www.scopus.com/pages/publications/85066264448
U2 - 10.1016/j.nicl.2019.101863
DO - 10.1016/j.nicl.2019.101863
M3 - 文章
C2 - 31158692
AN - SCOPUS:85066264448
SN - 2213-1582
VL - 23
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 101863
ER -