Evaluation of enzyme inhibition kinetics in drug-drug interactions

Ang Chen; Xuan Qin; Yu Tang; Mingyao Liu; Xin Wang

doi:10.1016/j.cbi.2014.10.010

Evaluation of enzyme inhibition kinetics in drug-drug interactions

Ang Chen
, Xuan Qin
, Yu Tang
, Mingyao Liu
, Xin Wang^*

^*此作品的通讯作者

生命科学学院

East China Normal University
Texas A&M University

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

源语言	英语
页（从-至）	133-134
页数	2
期刊	Chemico-Biological Interactions
卷	222
DOI	https://doi.org/10.1016/j.cbi.2014.10.010
出版状态	已出版 - 5 10月 2014

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10.1016/j.cbi.2014.10.010

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@article{897774995e834e17b9593cc31524c6bf,

title = "Evaluation of enzyme inhibition kinetics in drug-drug interactions",

abstract = "Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.",

keywords = "CYP enzymes, Drug-drug interactions, Enzyme inhibition kinetics",

author = "Ang Chen and Xuan Qin and Yu Tang and Mingyao Liu and Xin Wang",

year = "2014",

month = oct,

day = "5",

doi = "10.1016/j.cbi.2014.10.010",

language = "英语",

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pages = "133--134",

journal = "Chemico-Biological Interactions",

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TY - JOUR

T1 - Evaluation of enzyme inhibition kinetics in drug-drug interactions

AU - Chen, Ang

AU - Qin, Xuan

AU - Tang, Yu

AU - Liu, Mingyao

AU - Wang, Xin

PY - 2014/10/5

Y1 - 2014/10/5

N2 - Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

AB - Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

KW - CYP enzymes

KW - Drug-drug interactions

KW - Enzyme inhibition kinetics

UR - https://www.scopus.com/pages/publications/84908615051

U2 - 10.1016/j.cbi.2014.10.010

DO - 10.1016/j.cbi.2014.10.010

M3 - 文章

C2 - 25451570

AN - SCOPUS:84908615051

SN - 0009-2797

VL - 222

SP - 133

EP - 134

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

ER -

Evaluation of enzyme inhibition kinetics in drug-drug interactions

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