Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative

Wanwan Shen; Hongmei Liu; Ye Ling-Hu; Hui Wang; Yiyun Cheng

doi:10.1039/c6tb01218c

Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative

Wanwan Shen
, Hongmei Liu
, Ye Ling-Hu
, Hui Wang^*
, Yiyun Cheng

^*此作品的通讯作者

生命科学学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

7 引用（Scopus）

摘要

Lipid modification has been widely applied to improve the gene delivery efficacy of cationic polymers. However, this strategy is often associated with relatively low efficacy and high toxicity due to the inherent features of lipids. Here, we describe a novel and facile strategy to develop polymeric gene vectors via cyclododecylation of cationic dendrimers. The synthesized cyclododecylated dendrimer is much more efficient and biocompatible than the dodecylated analogues.

源语言	英语
页（从-至）	5654-5658
页数	5
期刊	Journal of Materials Chemistry B
卷	4
期	34
DOI	https://doi.org/10.1039/c6tb01218c
出版状态	已出版 - 2016

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10.1039/c6tb01218c

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title = "Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative",

abstract = "Lipid modification has been widely applied to improve the gene delivery efficacy of cationic polymers. However, this strategy is often associated with relatively low efficacy and high toxicity due to the inherent features of lipids. Here, we describe a novel and facile strategy to develop polymeric gene vectors via cyclododecylation of cationic dendrimers. The synthesized cyclododecylated dendrimer is much more efficient and biocompatible than the dodecylated analogues.",

author = "Wanwan Shen and Hongmei Liu and Ye Ling-Hu and Hui Wang and Yiyun Cheng",

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AU - Shen, Wanwan

AU - Liu, Hongmei

AU - Ling-Hu, Ye

AU - Wang, Hui

AU - Cheng, Yiyun

PY - 2016

Y1 - 2016

N2 - Lipid modification has been widely applied to improve the gene delivery efficacy of cationic polymers. However, this strategy is often associated with relatively low efficacy and high toxicity due to the inherent features of lipids. Here, we describe a novel and facile strategy to develop polymeric gene vectors via cyclododecylation of cationic dendrimers. The synthesized cyclododecylated dendrimer is much more efficient and biocompatible than the dodecylated analogues.

AB - Lipid modification has been widely applied to improve the gene delivery efficacy of cationic polymers. However, this strategy is often associated with relatively low efficacy and high toxicity due to the inherent features of lipids. Here, we describe a novel and facile strategy to develop polymeric gene vectors via cyclododecylation of cationic dendrimers. The synthesized cyclododecylated dendrimer is much more efficient and biocompatible than the dodecylated analogues.

UR - https://www.scopus.com/pages/publications/84985010352

U2 - 10.1039/c6tb01218c

DO - 10.1039/c6tb01218c

M3 - 文章

AN - SCOPUS:84985010352

SN - 2050-750X

VL - 4

SP - 5654

EP - 5658

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 34

ER -

Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative

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