Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes

Cai Wang; Ren Yi Zhu; Kui Liao; Feng Zhou; Jian Zhou

doi:10.1021/acs.orglett.9b04522

Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes

Cai Wang
, Ren Yi Zhu
, Kui Liao
, Feng Zhou^*
, Jian Zhou

^*此作品的通讯作者

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

29 引用（Scopus）

摘要

We report an unprecedented highly enantioselective desymmetric Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcohols bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.

源语言	英语
页（从-至）	1270-1274
页数	5
期刊	Organic Letters
卷	22
期	4
DOI	https://doi.org/10.1021/acs.orglett.9b04522
出版状态	已出版 - 21 2月 2020

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abstract = "We report an unprecedented highly enantioselective desymmetric Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcohols bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.",

author = "Cai Wang and Zhu, \{Ren Yi\} and Kui Liao and Feng Zhou and Jian Zhou",

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AU - Wang, Cai

AU - Zhu, Ren Yi

AU - Liao, Kui

AU - Zhou, Feng

AU - Zhou, Jian

PY - 2020/2/21

Y1 - 2020/2/21

N2 - We report an unprecedented highly enantioselective desymmetric Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcohols bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.

AB - We report an unprecedented highly enantioselective desymmetric Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcohols bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.

UR - https://www.scopus.com/pages/publications/85079030920

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DO - 10.1021/acs.orglett.9b04522

M3 - 文章

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AN - SCOPUS:85079030920

SN - 1523-7060

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SP - 1270

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JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes

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