Enantio-divergent C–H borylation with two different ligands from a single chiral source

Reported here is an iridium-catalyzed enantio-divergent C(sp³)-H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope. (Figure presented.)