Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-crafts cyclization of iodinated allylic alcohols

Xiaobo Zhou; Huimin Zhang; Xin Xie; Yanzhong Li

doi:10.1021/jo800232p

Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-crafts cyclization of iodinated allylic alcohols

Xiaobo Zhou
, Huimin Zhang
, Xin Xie
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

65 引用（Scopus）

摘要

(Chemical Equation Presented) A convenient BF₃·Et ₂O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.

源语言	英语
页（从-至）	3958-3960
页数	3
期刊	Journal of Organic Chemistry
卷	73
期	10
DOI	https://doi.org/10.1021/jo800232p
出版状态	已出版 - 16 5月 2008

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title = "Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-crafts cyclization of iodinated allylic alcohols",

abstract = "(Chemical Equation Presented) A convenient BF3·Et 2O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.",

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T1 - Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-crafts cyclization of iodinated allylic alcohols

AU - Zhou, Xiaobo

AU - Zhang, Huimin

AU - Xie, Xin

AU - Li, Yanzhong

PY - 2008/5/16

Y1 - 2008/5/16

N2 - (Chemical Equation Presented) A convenient BF3·Et 2O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.

AB - (Chemical Equation Presented) A convenient BF3·Et 2O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1H-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.

UR - https://www.scopus.com/pages/publications/43449130082

U2 - 10.1021/jo800232p

DO - 10.1021/jo800232p

M3 - 文章

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AN - SCOPUS:43449130082

SN - 0022-3263

VL - 73

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EP - 3960

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 10

ER -

Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-crafts cyclization of iodinated allylic alcohols

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