Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

Chengjin Wang; Shunying Liu; Dong Xing; Xin Wang; Xiang Wu; Wenhao Hu

doi:10.1016/j.tet.2013.10.046

Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

Chengjin Wang
, Shunying Liu^*
, Dong Xing
, Xin Wang
, Xiang Wu
, Wenhao Hu

^*此作品的通讯作者

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

15 引用（Scopus）

摘要

A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

源语言	英语
页（从-至）	11203-11208
页数	6
期刊	Tetrahedron
卷	69
期	52
DOI	https://doi.org/10.1016/j.tet.2013.10.046
出版状态	已出版 - 30 12月 2013

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title = "Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde",

abstract = "A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.",

keywords = "Aldol-type reaction, Ammonium ylide, Formaldehyde, Three-component reaction, α-Aryl serine derivatives",

author = "Chengjin Wang and Shunying Liu and Dong Xing and Xin Wang and Xiang Wu and Wenhao Hu",

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T1 - Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

AU - Wang, Chengjin

AU - Liu, Shunying

AU - Xing, Dong

AU - Wang, Xin

AU - Wu, Xiang

AU - Hu, Wenhao

PY - 2013/12/30

Y1 - 2013/12/30

N2 - A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

AB - A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

KW - Aldol-type reaction

KW - Ammonium ylide

KW - Formaldehyde

KW - Three-component reaction

KW - α-Aryl serine derivatives

UR - https://www.scopus.com/pages/publications/84889578475

U2 - 10.1016/j.tet.2013.10.046

DO - 10.1016/j.tet.2013.10.046

M3 - 文章

AN - SCOPUS:84889578475

SN - 0040-4020

VL - 69

SP - 11203

EP - 11208

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -

Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

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