Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Liu Hongying; Fang Juan; Li QingLi; Zhang Jingfa

doi:10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Liu Hongying
, Fang Juan
, Li QingLi
, Zhang Jingfa

通信与电子工程学院

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

摘要

AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

源语言	英语
主期刊名	Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
出版商	Institute of Electrical and Electronics Engineers Inc.
页	411-414
页数	4
ISBN（电子版）	9781467371438
DOI	https://doi.org/10.1109/ICMTMA.2015.105
出版状态	已出版 - 11 9月 2015
活动	7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 - Nanchang, Jiangxi, 中国期限: 13 6月 2015 → 14 6月 2015

出版系列

姓名	Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

会议

会议	7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
国家/地区	中国
市	Nanchang, Jiangxi
时期	13/06/15 → 14/06/15

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

访问文件

10.1109/ICMTMA.2015.105

其它文件与链接

链接到 Scopus 的出版物

引用此

Hongying, L., Juan, F., QingLi, L., & Jingfa, Z. (2015). Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. 在 Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 (页码 411-414). 文章 7263598 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICMTMA.2015.105

Hongying, Liu ; Juan, Fang ; QingLi, Li 等. / Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 页码 411-414 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015).

@inproceedings{788a32a07bbb4409b0a1ef1461f1ff1f,

title = "Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System",

abstract = "AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.",

keywords = "AAV2-EPO, Diabetic retinopathy, MHSI, ONL, Spectral Angle, qualitative analysis",

author = "Liu Hongying and Fang Juan and Li QingLi and Zhang Jingfa",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 ; Conference date: 13-06-2015 Through 14-06-2015",

year = "2015",

month = sep,

day = "11",

doi = "10.1109/ICMTMA.2015.105",

language = "英语",

series = "Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "411--414",

booktitle = "Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015",

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}

Hongying, L, Juan, F, QingLi, L & Jingfa, Z 2015, Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. 在 Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015., 7263598, Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015, Institute of Electrical and Electronics Engineers Inc., 页码 411-414, 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015, Nanchang, Jiangxi, 中国, 13/06/15. https://doi.org/10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. / Hongying, Liu; Juan, Fang; QingLi, Li 等.
Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 页码 411-414 7263598 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

AU - Hongying, Liu

AU - Juan, Fang

AU - QingLi, Li

AU - Jingfa, Zhang

PY - 2015/9/11

Y1 - 2015/9/11

N2 - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

AB - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

KW - AAV2-EPO

KW - Diabetic retinopathy

KW - MHSI

KW - ONL

KW - Spectral Angle

KW - qualitative analysis

UR - https://www.scopus.com/pages/publications/84960130722

U2 - 10.1109/ICMTMA.2015.105

DO - 10.1109/ICMTMA.2015.105

M3 - 会议稿件

AN - SCOPUS:84960130722

T3 - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

SP - 411

EP - 414

BT - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

Y2 - 13 June 2015 through 14 June 2015

ER -

Hongying L, Juan F, QingLi L, Jingfa Z. Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. 在 Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 页码 411-414. 7263598. (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015). doi: 10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

摘要

出版系列

会议

联合国可持续发展目标

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