TY - JOUR
T1 - Effective asymmetric synthesis of the key chiral building blocks of 20(S)- and 20(R)-camptothecins
AU - Yu, Sanbao
AU - Feng, Xiangjun
AU - Luo, Yu
AU - Lu, Wei
PY - 2012/4
Y1 - 2012/4
N2 - An effective diastereoselective synthesis of (S)- N,N-diethyl-2-formyl-2- (methoxymethoxy)butanamide and (S)-2-formyl-2-(methoxymethoxy)butanoic acid ethyl ester, which are two key chiral building blocks for the synthesis of 20(S)-camptothecins, has been developed by employing an asymmetric bromolactonization using (R)-proline. The (R) compounds were also synthesized to obtain 20(R)- camptothecin.
AB - An effective diastereoselective synthesis of (S)- N,N-diethyl-2-formyl-2- (methoxymethoxy)butanamide and (S)-2-formyl-2-(methoxymethoxy)butanoic acid ethyl ester, which are two key chiral building blocks for the synthesis of 20(S)-camptothecins, has been developed by employing an asymmetric bromolactonization using (R)-proline. The (R) compounds were also synthesized to obtain 20(R)- camptothecin.
KW - (R)-Proline
KW - (S)-N,N-Diethyl-2-formyl-2-(methoxymethoxy)- butanamide
KW - 20(S)-Camptothecins
KW - Asymmetric bromolactonization
KW - Diastereoselective synthesis
UR - https://www.scopus.com/pages/publications/84859266282
U2 - 10.1007/s00706-011-0617-0
DO - 10.1007/s00706-011-0617-0
M3 - 文章
AN - SCOPUS:84859266282
SN - 0026-9247
VL - 143
SP - 675
EP - 681
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 4
ER -