Drug Design of “Undruggable” Targets

Jie Wang; Shiliang Li; Honglin Li

doi:10.1002/cjoc.201800552

Drug Design of “Undruggable” Targets

Jie Wang
, Shiliang Li
, Honglin Li^*

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文献综述 › 同行评审

9 引用（Scopus）

摘要

Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as “undruggable”. In this review, we summarized the current situation of “undruggable” targets, and the design strategies for “undruggable” targets, hoping to provide references for the development of innovative drugs.

源语言	英语
页（从-至）	501-512
页数	12
期刊	Chinese Journal of Chemistry
卷	37
期	5
DOI	https://doi.org/10.1002/cjoc.201800552
出版状态	已出版 - 1 5月 2019
已对外发布	是

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title = "Drug Design of “Undruggable” Targets",

abstract = "Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as “undruggable”. In this review, we summarized the current situation of “undruggable” targets, and the design strategies for “undruggable” targets, hoping to provide references for the development of innovative drugs.",

keywords = "RAS, RNA, drug design, phosphatases, protein-protein interactions, transcription factors, “undruggable” targets",

author = "Jie Wang and Shiliang Li and Honglin Li",

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year = "2019",

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AU - Wang, Jie

AU - Li, Shiliang

AU - Li, Honglin

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N2 - Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as “undruggable”. In this review, we summarized the current situation of “undruggable” targets, and the design strategies for “undruggable” targets, hoping to provide references for the development of innovative drugs.

AB - Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as “undruggable”. In this review, we summarized the current situation of “undruggable” targets, and the design strategies for “undruggable” targets, hoping to provide references for the development of innovative drugs.

KW - RAS

KW - RNA

KW - drug design

KW - phosphatases

KW - protein-protein interactions

KW - transcription factors

KW - “undruggable” targets

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DO - 10.1002/cjoc.201800552

M3 - 文献综述

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VL - 37

SP - 501

EP - 512

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 5

ER -

Drug Design of “Undruggable” Targets

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