Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin

Xiongwen Zhang; Yanhua Zhou; Bin Xu

Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin

Xiongwen Zhang
, Yanhua Zhou
, Bin Xu

Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

7 引用（Scopus）

摘要

Objective: To study the differentiation-inducing effect of hydroxycamptothecin (HCPT) on hepatoma Hep G2 cells. Methods: 3-[4, 5-dimethylthial-2-yl]-3, 5-diphenyltetrazolinium bromide (MTT) colorimetric method was used for determining HepG2 cells viability. Alphafetoprotein (AFP) and albumin (ALB) levels were determined with Elisa Kits. Results: The AFP secretion of HCPT-treated cells was reduced by 44.0%-49.2% while the ALB level was increased markedly. Conclusion: Hydroxycamptothecin can induce human hepatoma Hep G2 cells to differentiation.

源语言	英语
页（从-至）	712-713
页数	2
期刊	Chinese Medical Journal
卷	113
期	8
出版状态	已出版 - 8月 2000
已对外发布	是

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title = "Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin",

abstract = "Objective: To study the differentiation-inducing effect of hydroxycamptothecin (HCPT) on hepatoma Hep G2 cells. Methods: 3-[4, 5-dimethylthial-2-yl]-3, 5-diphenyltetrazolinium bromide (MTT) colorimetric method was used for determining HepG2 cells viability. Alphafetoprotein (AFP) and albumin (ALB) levels were determined with Elisa Kits. Results: The AFP secretion of HCPT-treated cells was reduced by 44.0\%-49.2\% while the ALB level was increased markedly. Conclusion: Hydroxycamptothecin can induce human hepatoma Hep G2 cells to differentiation.",

keywords = "Differentiation, Hepatoma cells, Hydroxycamptothecin",

author = "Xiongwen Zhang and Yanhua Zhou and Bin Xu",

year = "2000",

month = aug,

language = "英语",

volume = "113",

pages = "712--713",

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TY - JOUR

T1 - Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin

AU - Zhang, Xiongwen

AU - Zhou, Yanhua

AU - Xu, Bin

PY - 2000/8

Y1 - 2000/8

N2 - Objective: To study the differentiation-inducing effect of hydroxycamptothecin (HCPT) on hepatoma Hep G2 cells. Methods: 3-[4, 5-dimethylthial-2-yl]-3, 5-diphenyltetrazolinium bromide (MTT) colorimetric method was used for determining HepG2 cells viability. Alphafetoprotein (AFP) and albumin (ALB) levels were determined with Elisa Kits. Results: The AFP secretion of HCPT-treated cells was reduced by 44.0%-49.2% while the ALB level was increased markedly. Conclusion: Hydroxycamptothecin can induce human hepatoma Hep G2 cells to differentiation.

AB - Objective: To study the differentiation-inducing effect of hydroxycamptothecin (HCPT) on hepatoma Hep G2 cells. Methods: 3-[4, 5-dimethylthial-2-yl]-3, 5-diphenyltetrazolinium bromide (MTT) colorimetric method was used for determining HepG2 cells viability. Alphafetoprotein (AFP) and albumin (ALB) levels were determined with Elisa Kits. Results: The AFP secretion of HCPT-treated cells was reduced by 44.0%-49.2% while the ALB level was increased markedly. Conclusion: Hydroxycamptothecin can induce human hepatoma Hep G2 cells to differentiation.

KW - Differentiation

KW - Hepatoma cells

KW - Hydroxycamptothecin

UR - https://www.scopus.com/pages/publications/0343526438

M3 - 文章

C2 - 11776054

AN - SCOPUS:0343526438

SN - 0366-6999

VL - 113

SP - 712

EP - 713

JO - Chinese Medical Journal

JF - Chinese Medical Journal

IS - 8

ER -

Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin

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