Designed Microdevices for In Vitro Diagnostics

In vitro diagnostics (IVD) refers to in vitro tests of biological specimens and contributes to two-thirds of clinical diagnosis. There are two major compo-nents to consider for the construction of devices for IVD, including: i) capture and recognition; and ii) detection methods. Herein, the principle, design, and application of microdevices regarding these two routes in recent progress for IVD are shown. Microarrays, microfluidics, and nanodevices are reviewed for capture and recognition. Mass spectrometry, fluorescence, electrochemistry, and so on are summarized as detection methods. The roles of materials in devices toward diverse applications are elucidated with the aims of designing materials for high-performance device toward precision medicine and initiating the development of advanced diagnostic tools involving various biomarkers.