Copper-free Sonogashira reaction using 7-chloro camptothecins

Yu Luo; Heyong Gao; Yunfei Li; Weigang Huang; Wei Lu; Zhaoguo Zhang

doi:10.1016/j.tet.2006.01.001

Copper-free Sonogashira reaction using 7-chloro camptothecins

Yu Luo
, Heyong Gao
, Yunfei Li
, Weigang Huang
, Wei Lu^*
, Zhaoguo Zhang

^*此作品的通讯作者

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

29 引用（Scopus）

摘要

We studied copper-free Sonogashira reaction using 7-chloro camptothecins, and determined that rac-BINAP/Pd(OAc)₂ was an efficient catalyst for the coupling reaction. With this process, a number of 7-substituted camptothecins with a wide range of functional groups are potentially accessible. Besides, two drugs, SN-38 and BNP-1350, could be prepared by this method.

源语言	英语
页（从-至）	2465-2470
页数	6
期刊	Tetrahedron
卷	62
期	11
DOI	https://doi.org/10.1016/j.tet.2006.01.001
出版状态	已出版 - 13 3月 2006

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10.1016/j.tet.2006.01.001

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@article{2b4142820aae444685228952ed998763,

title = "Copper-free Sonogashira reaction using 7-chloro camptothecins",

abstract = "We studied copper-free Sonogashira reaction using 7-chloro camptothecins, and determined that rac-BINAP/Pd(OAc)2 was an efficient catalyst for the coupling reaction. With this process, a number of 7-substituted camptothecins with a wide range of functional groups are potentially accessible. Besides, two drugs, SN-38 and BNP-1350, could be prepared by this method.",

keywords = "Camptothecin, Catalysis, Palladium, Sonogashira coupling, Topoisomerase I",

author = "Yu Luo and Heyong Gao and Yunfei Li and Weigang Huang and Wei Lu and Zhaoguo Zhang",

year = "2006",

month = mar,

day = "13",

doi = "10.1016/j.tet.2006.01.001",

language = "英语",

volume = "62",

pages = "2465--2470",

journal = "Tetrahedron",

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TY - JOUR

T1 - Copper-free Sonogashira reaction using 7-chloro camptothecins

AU - Luo, Yu

AU - Gao, Heyong

AU - Li, Yunfei

AU - Huang, Weigang

AU - Lu, Wei

AU - Zhang, Zhaoguo

PY - 2006/3/13

Y1 - 2006/3/13

N2 - We studied copper-free Sonogashira reaction using 7-chloro camptothecins, and determined that rac-BINAP/Pd(OAc)2 was an efficient catalyst for the coupling reaction. With this process, a number of 7-substituted camptothecins with a wide range of functional groups are potentially accessible. Besides, two drugs, SN-38 and BNP-1350, could be prepared by this method.

AB - We studied copper-free Sonogashira reaction using 7-chloro camptothecins, and determined that rac-BINAP/Pd(OAc)2 was an efficient catalyst for the coupling reaction. With this process, a number of 7-substituted camptothecins with a wide range of functional groups are potentially accessible. Besides, two drugs, SN-38 and BNP-1350, could be prepared by this method.

KW - Camptothecin

KW - Catalysis

KW - Palladium

KW - Sonogashira coupling

KW - Topoisomerase I

UR - https://www.scopus.com/pages/publications/32644453360

U2 - 10.1016/j.tet.2006.01.001

DO - 10.1016/j.tet.2006.01.001

M3 - 文章

AN - SCOPUS:32644453360

SN - 0040-4020

VL - 62

SP - 2465

EP - 2470

JO - Tetrahedron

JF - Tetrahedron

IS - 11

ER -

Copper-free Sonogashira reaction using 7-chloro camptothecins

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