Contamination distribution and non-biological removal pathways of typical tetracycline antibiotics in the environment: A review

While the occurrence and removal technologies of tetracyclines in the environment have been reported, a comprehensive systematic summary and analysis remain limited, especially for new generations compounds such as doxycycline. In this review, the latest information regarding the distribution of various tetracyclines in different countries over the past seven years (2017–2023) reveals a notable absence of research reports in North America and Oceania. With China as the representative country, the investigation indicates that the maximum concentrations of TCs exceed 5 µg/L. The maximum concentration of tetracyclines in feces (26.22 µg/L) can reach one order of magnitude higher than that in other media. Furthermore, advanced oxidation technologies, such as Fenton processes, electrochemical oxidation, photolysis, ozonation, etc., were also examined, and the median degradation rate achieved 91.9–97.67%. Reactions such as methylation, demethylation, hydroxylation, dehydration, ring cleavage, and oxidation were observed during degradation. The most common intermediate product was identified as m/z = 461 (C₂₂H₂₅N₂O₉). This review indicates that future efforts should emphasize understanding the occurrence and fate of new-generation tetracyclines in the environment.