Construction of the basic skeleton of ophiobolin A and variecolin

Ke Li; Cheng Wang; Gang Yin; Shuanhu Gao

doi:10.1039/c3ob41693c

Construction of the basic skeleton of ophiobolin A and variecolin

Ke Li
, Cheng Wang
, Gang Yin
, Shuanhu Gao^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

24 引用（Scopus）

摘要

Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.

源语言	英语
页（从-至）	7550-7558
页数	9
期刊	Organic and Biomolecular Chemistry
卷	11
期	43
DOI	https://doi.org/10.1039/c3ob41693c
出版状态	已出版 - 21 11月 2013

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AB - Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.

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M3 - 文章

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ER -

Construction of the basic skeleton of ophiobolin A and variecolin

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