Confined synthesis of homogeneous Tetrakis(triphenyl phosphine) palladium within hollow porous polymeric nanospheres for catalysis application

In this paper, we report a facile “ship-in-bottle” confined synthesis method to encapsulate the large-sized homogeneous tetrakis(triphenyl phosphine) palladium (Pd(PPh₃)₄) catalyst into hyper-crosslinked hollow porous polymeric nanospheres (H-PPNs). The hyper-crosslinked microporous shell can prevent the free Pd(PPh₃)₄ molecules escaping from the cavity in H-PPNs. The obtained Pd(PPh₃)₄@H-PPNs catalysts not only retain the high catalytic reactivity (>99%) of homogeneous Pd(PPh₃)₄ for Suzuki−Miyaura (turnover of frequency of 2829 h⁻¹) and Heck cross-coupling reactions, but also show outstanding reusability just like that of heterogeneous catalysis system.