Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

Murong Xu; Yang Yuan; Ye Wang; Yuanyang Mu; Huihui Xie; Yanzhong Li

doi:10.1016/j.tetlet.2021.152872

Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

Murong Xu
, Yang Yuan
, Ye Wang
, Yuanyang Mu
, Huihui Xie
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

15 引用（Scopus）

摘要

A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

源语言	英语
期刊论文编号	152872
期刊	Tetrahedron Letters
卷	70
DOI	https://doi.org/10.1016/j.tetlet.2021.152872
出版状态	已出版 - 27 4月 2021

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10.1016/j.tetlet.2021.152872

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@article{bb626123d1724d4bac6b815c6a98a834,

title = "Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides",

abstract = "A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.",

keywords = "C[sbnd]H activation, Chelation-assisted, Cobalt, Regioselectivity, Spirosuccinimide",

author = "Murong Xu and Yang Yuan and Ye Wang and Yuanyang Mu and Huihui Xie and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = apr,

day = "27",

doi = "10.1016/j.tetlet.2021.152872",

language = "英语",

volume = "70",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides

T2 - Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

AU - Xu, Murong

AU - Yuan, Yang

AU - Wang, Ye

AU - Mu, Yuanyang

AU - Xie, Huihui

AU - Li, Yanzhong

PY - 2021/4/27

Y1 - 2021/4/27

N2 - A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

AB - A cobalt-catalyzed C[sbnd]H activation/cyclization of N-carbamoyl indole/benzamides with maleimides assisted by pyridinylmethylamine under mild reaction conditions is described. The synthetic strategy was developed to access imidazo[1,5-a]indole-/isoindolone-incorporated spirosuccinimides with a broad substrate scope and high regiospecificity.

KW - C[sbnd]H activation

KW - Chelation-assisted

KW - Cobalt

KW - Regioselectivity

KW - Spirosuccinimide

UR - https://www.scopus.com/pages/publications/85103235531

U2 - 10.1016/j.tetlet.2021.152872

DO - 10.1016/j.tetlet.2021.152872

M3 - 文章

AN - SCOPUS:85103235531

SN - 0040-4039

VL - 70

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 152872

ER -

Cobalt-catalyzed C[sbnd]H activation of N-carbamoyl indoles or benzamides with maleimides: Synthesis of imidazo[1,5-a]indole- or isoindolone-incorporated spirosuccinimides

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